Endocrine Abstracts

An 89 years old caucasian female patient with antecedents of hemithyroidectomy in 2016 due to benign nodular disease, and actually suplemented with 0.1 mg/day of levothyroxine, was referred to the Endocrinology consultation because of a primary hyperparathyroidism diagnosed in the sequence of the study of an episode of nephrolitiasis that happened in 2012 and a diagnosis of osteoporosis that was established in 2017. A 99mTc-Sestamibi revealed an augmented right inferior parath...

Introduction: Diabetes mellitus (DM) results from a defect in insulin secretion and/or its action. The Breast-Cancer Susceptibility Gene 2 (BRCA2), like BRCA1, is a tumour suppressor gene, and its mutation is associated with an increased risk of breast cancer and, in males, testicular cancer. In patients with the BRCA1/2 mutation, the level of Insulin-like Growth Factor (IGF)-1 and, consequently, the peripheral sensitivity to insulin are reduced, suggesting that this ...

Introduction: Recent studies seem to support a bidirectional positive interaction between aldosterone and parathyroid hormone (PTH). Understanding the normal physiological relationship between renin-angiotensin-aldosterone system (RAAS) and PTH is of clinical interest because their inappropriate activity may negatively impact cardiovascular and skeletal health.Objective: To evaluate the presence of an interaction between aldosterone and PTH in a cohort o...

Introduction: Autoimmune Addison disease requires lifelong glucocorticoid and mineralocorticoid replacement. Optimal therapy is not standardized and must balance adequate hormone substitution with prevention of treatment-related complications.Objective: Assessment of patients followed at our department: epidemiology, associated conditions, treatment, cumulative hydrocortisone dose and comorbidities.Methods: Review of clinical recor...

Introduction: Obesity is a chronic disease associated with multiple comorbidities, defined by BMI, without considering the metabolic state of the patient. There are few data on the proportion of obese patients without metabolic syndrome (MS).Objective: To characterize patients considered to be metabolically healthy (MH) followed at the obesity outpatient clinic of one University Hospital, and to compare this group with a group of obese patients with MS.<...

BackgroundAutosomal dominant hypocalcaemia, caused by either inherited or de novo mutations in calcium-sensing receptor gene (CASR), is biochemically characterized by the presence of hypocalcaemia, hypercalciuria and inappropriately low levels of PTH. Receptor-activating mutations induce an increase sensitivity to calcium by parathyroid and renal cells, leading to suppression of PTH synthesis and consequently hypocalcaemia. Clinical manifestations are va...

Introduction: Thyroglossal duct cysts (TDC) are a very frequent congenital neck mass and are mostly benign. Papillary thyroid carcinoma (PTC) originating from a TDC represents an infrequent finding. Usually, the diagnosis is only made postoperatively after cyst’s excision.Case report: A 38-years old female patient was referred to the Endocrinology department due to Graves’ disease. She had been treated with antithyroid drugs for 18 months witho...

Introduction and purpose: 177Lu-[DOTA0,Tyr3]octreotate (177Lu-DOTA-TATE) is a radiopharmaceutical frequently used in peptide receptor radionuclide therapy (PRRT), which is a promising treatment modality in patients with metastasized neuroendocrine tumors (NETs). We purpose to evaluate the quality of life (QoL) in patients with somatostatin receptor positive inoperable or metastatic NETs throughout the three cycle’s (with three months intervals) proto...

Background: Low serum testosterone (LST) is associated with some chronic diseases, changes in body composition and resistance to insulin. Diabetes is one condition that has high prevalence of LST.Objetive: To determine the prevalence of LST in men with diabetes and its relationship with age, anthropometric and biochemical data.Material and methods: A cross-sectional study of 65 men with type 1 and type 2 diabetes was conducted, wit...

Background: In the recent years, Vitamin D role has grown in cardiovascular and inflammatory diseases, and some relations were made with low serum testosterone (LST) levels. It is equally known that in patients with diabetes, the prevalence of LST is higher.Objetive: To determine the prevalence of low levels of vitamin D and its relation with LST in men with diabetes.Material and methods: A cross-sectional study of 65 men with type...